Nuclear Import of Serum Response Factor in Airway Smooth Muscle
نویسندگان
چکیده
منابع مشابه
Airway smooth muscle relaxation.
Bronchodilators are important agents in the treatment of asthma and chronic obstructive airways disease. Beta agonists, theophyllines, and antimuscarinic agents are the main drugs in current use, but others are under investigation. Although other actions may be important, these drugs produce bronchodilation either by a direct effect on airway smooth muscle or by inhibiting neural pathways. As o...
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Previous studies have shown that multiple serum response factor (SRF)-binding CArG elements were required for smooth muscle cell (SMC)-specific regulation of smooth muscle (SM) alpha-actin expression. However, a critical question remains as to the mechanisms whereby a ubiquitously expressed transcription factor such as SRF might contribute to SMC-specific expression. The goal of the present stu...
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BACKGROUND Halothane relaxes airway smooth muscle, in part, by decreasing the force produced for a given intracellular [Ca(2+)] (i.e., Ca(2+) sensitivity) during muscarinic stimulation, an effect produced by a decrease in regulatory myosin light-chain (rMLC) phosphorylation. The authors tested the hypothesis that halothane reduces rMLC phosphorylation during muscarinic stimulation at constant i...
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In 1966, BARBARO and ZvAIFLER [l] demonstrated the release of histamine from rabbit platelets during an acute allergic response. Five years later, it was shown that a soluble factor from leucocytes, capable of inducing platelet activation, was responsible for this effect [2, 3). In subsequent years, the factor was recognized for its potent ability to s timulate platelet aggregation and secretio...
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ژورنال
عنوان ژورنال: American Journal of Respiratory Cell and Molecular Biology
سال: 2011
ISSN: 1044-1549,1535-4989
DOI: 10.1165/rcmb.2008-0393oc